Inhibition of testosterone 5α-reductase activity and growth of accessory sex tissues in castrated male mice

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Authors:
W. G. Luttge
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,
T. W. Jasper
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C. S. Sheets
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, and
H. E. Gray
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DOI:
https://doi.org/10.1530/jrf.0.0530045
Volume/Issue:
Volume 53: Issue 1
Page Range:
45–50
Article Type:
Research Article
Online Publication Date:
May 1978
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Summary. The steroid 4-androsten-3-one-17β-carboxylic acid (17βC) reduced the growth-promoting actions of testosterone, but not those of DHT in accessory sex tissues of castrated mice. The 5α-reduction of testosterone to DHT in these tissues was also reduced by 17βC treatment, suggesting that DHT formation is a required step in the mechanism of action of testosterone.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899