Preovulatory secretion of gonadotrophins and TSH in cyclic rats with small lesions in the preoptic area

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Authors:
R. G. Dyer
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,
M. B. ter Haar
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, and
D. Saphier
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DOI:
https://doi.org/10.1530/jrf.0.0530085
Volume/Issue:
Volume 53: Issue 1
Page Range:
85–89
Article Type:
Research Article
Online Publication Date:
May 1978
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Summary. Animals with unilateral or bilateral lesions, with respectively 85 and 70% of intact preoptic area tissue remaining, returned to regular oestrous cycles. By comparison with sham-operated controls, rats with lesions had more days with a leucocytic smear in each of the 1st, 2nd or 3rd post-operative cycle, before returning to a 4-day cycle. Hormone measurements of blood collected during the afternoon of pro-oestrus showed that, in rats with bilateral lesions, the duration of the preovulatory LH secretion was significantly shortened, although peak levels were unchanged; the initial phase of the preovulatory FSH secretion was lost; and much of the prolactin surge was also inhibited. The TSH surge was unaffected.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899