Modification of oestrogen-induced uterine hyperaemia by drugs in the ovariectomized rat

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Authors:
S. Phaily
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Judith Senior
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DOI:
https://doi.org/10.1530/jrf.0.0530091
Volume/Issue:
Volume 53: Issue 1
Page Range:
91–97
Article Type:
Research Article
Online Publication Date:
May 1978
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Summary. Uterine blood flow in ovariectomized rats was measured by means of radioactive microspheres. Blood flow was increased from 55 ml min−1 100 g−1 by treatment (i.v.) with 0·5 μg oestradiol kg−1 and reached 680 ml min−1100 g−1 within 60 min. This oestrogen-induced increase of blood flow was reduced significantly by pretreatment with mepyramine (a histamine H1-receptor antagonist), cellulose sulphate (a kininogendepleting agent) and aprotinin (a kininogenase inhibitor). Cimetidine (a histamine H2-receptor antagonist), kallikrein (kininogenase enzyme) and atropine (an anticholinergic drug) had no effect on the increased uterine blood flow. Indomethacin and AH 7170, which inhibit the formation of prostaglandins, also caused a lower increase in uterine blood flow. None of the pretreatments fully inhibited the oestrogen-induced increase in blood flow, suggesting that more than one mediator may be involved.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899