It has been suggested by Shelesnyak (1957) that histamine might be the chemical stimulus responsible for the implantation of blastocysts. According to Shelesnyak's hypothesis (1960), an oestrogen surge results in the liberation of histamine, and the released histamine induces stromal cells of the endometrium to transform into decidual cells. Much of the experimental work supporting this hypothesis rests on the observation that, in rats, local application of antihistamine agents to the uterus suppresses the decidual transformation and inhibits the normal implantation of blastocysts.The possibility remains, however, that the effects of the antihistamines described by Shelesnyak may be non-specific, and interfere with implantation in some manner not involving histamine. The experiments described in the present report were undertaken in an attempt to extend the evidence concerning the possible role of histamine in the process of implantation.
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