Inhibition of fertilization in the hamster by sodium aurothiomalate, a hyaluronidase inhibitor

in Reproduction
View More View Less

Summary. Sodium aurothiomalate, a low molecular weight inhibitor of hyaluronidase, blocked in-vitro fertilization in hamsters at the level of the zona pellucida: concentrations of 25–250 pg inhibitor/ml prevented fertilization of cumulus-intact and cumulus-denuded eggs. Fertilization of zona-free ova was not affected. In-vivo fertilization was also reduced (from 100% in controls to 37·5%) by 10 mg inhibitor/ml added to an epididymal sperm suspension before artificial insemination into the uterus. These findings suggest that hyaluronidase may play a role in zona penetration or that sodium aurothiomalate blocks sperm penetration of the zona by inhibiting an enzyme(s) other than hyaluronidase.

If the inline PDF is not rendering correctly, you can download the PDF file here.


     An official journal of

    Society for Reproduction and Fertility


Sept 2018 onwards Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 237 23 3
PDF Downloads 225 53 5