Effect of hCG, cAMP and FSH on steroidogenesis by human corpora lutea in vitro

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Authors:
Morag G. Hunter
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T. G. Baker
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DOI:
https://doi.org/10.1530/jrf.0.0630285
Volume/Issue:
Volume 63: Issue 2
Page Range:
285–288
Article Type:
Research Article
Online Publication Date:
Nov 1981
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Summary. Human corpora lutea of various ages were minced and incubated in the presence of hCG (10 i.u./ml), cAMP (10 mm) or FSH (20 mu/ml) and production of progesterone and oestradiol was measured. Cyclic AMP and hCG stimulated progesterone and oestradiol production during at least the mid- and late luteal phases, but FSH stimulated only oestradiol production during the early and mid-luteal phases and had no effect on progesterone production. This demonstrates that progesterone and oestradiol synthesis by the human corpus luteum can be independently controlled.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899