Effect with time of a norepinephrine synthesis inhibitor (U-14,624) on hypothalamic catecholamine and plasma gonadotrophin concentrations in the ovariectomized rat
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Summary. Injection of the dopamine hydroxylase inhibitor U-14,624, to ovariectomized rats resulted in the reduction of hypothalamic norepinephrine concentration over a 48-h period and the elevation of hypothalamic dopamine concentration over a 24-h period. Plasma LH and FSH levels were markedly suppressed up to 48 h after drug treatment. These results suggest that U-14,624 is a much more potent inhibitor of gonadotrophin secretion than has been previously reported.
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