The regulation of pregnancy-associated murine protein 1 by gonadal steroids
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Summary. Pregnancy-associated murine protein 1 (PAMP-1) was present in the circulation of all mice at 1-day of age but not at Days 2–20. PAMP-1 values were low in juvenile male mice during puberty but had reached normal adult female levels within 35 days of birth in females. Concentrations in castrated males were similar to those of non-pregnant females within 6 weeks of operation. Testosterone treatment of castrated males and sexually mature females, and ovariectomy of adult females resulted in a significant fall in PAMP-1 concentrations. It is concluded that PAMP-1 is sex-steroid dependent.
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