A possible role of prostaglandin F-2α in the development of ovarian follicles in guinea-pigs

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Authors:
W. H. Tam
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R. J. J. Roy
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DOI:
https://doi.org/10.1530/jrf.0.0660277
Volume/Issue:
Volume 66: Issue 1
Page Range:
277–282
Article Type:
Research Article
Online Publication Date:
Sep 1982
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Summary. Uterine PGF-2α in the guinea-pig was eliminated by hysterectomy on Day 9 of the oestrous cycle and an increasing period of reduced PGF-2α availability to the ovary was created by deferring replacement therapy with PGF-2α from Day 9 to Day 11, 13 and 15. Ovulation, observed in 94% of the animals, was inevitably delayed. The treatment cycle length was progressively extended from the normal 15–16 days to 19–21 days. Similar results were obtained if endogenous PGF-2α was suppressed by indomethacin injection instead of removing the uterus. That ovulation had been delayed and not occurred from more recently recruited follicles was evident from the total absence of atretic follicles of the expected size had they become atretic due to the lack of PGF-2α at some critical time between Days 9 and 15. Pituitary homogenate and hCG injected on Day 16 shortened the PGF-2α treatment cycle by 2 days, but stimulated ovulation in only 42% of the animals. When endogenous PGF-2α was eliminated by hysterectomy and daily injections of indomethacin, follicular development ceased at approximately 0·8 mm instead of the 1·0 mm diameter found just before the preovulatory LH surge. It is suggested that (1) PGF-2α has to act on developing follicles for a given period before they are capable of ovulation, and (2) that PGF-2α is one of the factors required to stimulate the growth of the Graafian follicles at the end of the oestrous cycle.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899