Inhibition by PGI-2 of myometrial activity in vivo in non-pregnant ovariectomized sheep

in Reproduction
Authors:
S. J. Lye
Search for other papers by S. J. Lye in
Current site
Google Scholar
PubMed Close
and
J. R. G. Challis
Search for other papers by J. R. G. Challis in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.1530/jrf.0.0660311
Volume/Issue:
Volume 66: Issue 1
Page Range:
311–315
Article Type:
Research Article
Online Publication Date:
Sep 1982
Free access

Sign up for journal news

Summary. The effects of PGI-salt and PGI-2 methyl ester on intrauterine pressure (IUP) and uterine electromyographic activity (EMG) were examined in vivo in non-pregnant ovariectomized sheep. PGI-2 salt and PGI-2 methyl ester (50–200 μg) reduced significantly the frequency and amplitude of IUP cycles and also inhibited the associated uterine EMG activity. Injections of oxytocin (50 mU) or PGF-2α (2 μg) partly overcame the inhibition of IUP induced by the PGI-2 methyl ester. These results suggest that endogenous PGI-2 may be involved in the regulation of uterine activity in sheep.

Reproduction is committed to supporting researchers in demonstrating the impact of their articles published in the journal.

The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.

More information is on the Reasons to publish page.

Sept 2018 onwards Past Year Past 30 Days
Full Text Views 138 47 11
PDF Downloads 130 34 10

 

  • Collapse
  • Expand
Print ISSN:
1470-1626
Online ISSN:
1741-7899