Effect of PGF-2α on uterine activity, and concentrations of 13,14-dihydro-15-keto-PGF-2α in peripheral plasma during parturition in the tammar wallaby (Macropus eugenii)
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Summary. Intravenous administration of PGF-2α or an analogue stimulated uterine contractility in gravid uteri during seasonal quiescence and late pregnancy. The exogenous PGF-2α was metabolized to 13,14-dihydro-15-keto-PGF-2α (PGFM) which was assayed in peripheral plasma by a radioimmunoassay. PGFM was cleared from the circulation with a half life of 8–15 min. Blood samples were taken approximately every 6 h from Day 26 to Day 30 from tammars which were expected to give birth on Day 27– 28. Basal levels of PGFM were <400 pg/ml, and only occasional samples contained higher PGFM concentrations. Therefore, if uterine PGF-2α release is elevated at parturition in tammars, the corresponding rise of circulating PGFM is either small or of short duration.
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