Differential effects of LH-RH immunoneutralization on LH and FSH secretion in the ewe

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Authors:
H. M. Fraser
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A. S. McNeilly
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DOI:
https://doi.org/10.1530/jrf.0.0690569
Volume/Issue:
Volume 69: Issue 2
Page Range:
569–577
Article Type:
Research Article
Online Publication Date:
Nov 1983
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Summary. Neutralization of LH-RH by injection of an ovine antiserum to LH-RH in ewes during the late follicular phase of the oestrous cycle resulted in an immediate blockade of pulsatile secretion of LH. Plasma concentrations of FSH gradually rose in the antiserum-treated ewes during the 36-h study period but levels declined in control ewes. These results show that, in the ewe, pulsatile LH secretion is dependent on LH-RH from the hypothalamus, while FSH is largely unresponsive to short-term reduction of LH-RH stimulation. Since reduction in LH secretion is likely to reduce ovarian function, the changes in FSH secretion may be attributed to the removal of a negative feedback influence of an ovarian factor, perhaps oestradiol, on FSH secretion.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899