The case of a male eunuchoid aged 32 years is described. Of 46 XY karyotype, his testes showed complete absence of spermatogenesis. Small immature hyalinized tubules were lined only with Sertoli cells, and Leydig cells were difficult to find. After treatment for 8 years with androgens, at first by injection and for the rest of the time by mouth, he developed full virilization and later fertility. His wife became pregnant and gave birth to a child with cyanotic congenital heart disease.
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