Effects of gossypol on sperm counts in two inbred strains of mice

in Reproduction
Authors:
Suzan Hunt
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Ursula Mittwoch
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DOI:
https://doi.org/10.1530/jrf.0.0700341
Volume/Issue:
Volume 70: Issue 1
Page Range:
341–345
Article Type:
Research Article
Online Publication Date:
Jan 1984
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Summary. Gossypol acetic acid was administered orally to mice of two inbred strains, BALB/c/O1a and CBA/Gr, at daily doses of 10 or 20 mg/kg for about 4 weeks. Treated mice of both strains showed a reduction in sperm counts. This was more marked in CBA mice, which also had smaller testes size than did BALB/c mice. The treatment had no significant effect on testicular weight but the caput epididymidis and seminal vesicles of treated mice weighed less than those of control mice.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899