Summary. Cryptorchidism was associated with increased responsiveness of the isoproterenol-sensitive adenylate cyclase in membrane particles from rat testis. Abdominal testes from uni- and bilaterally cryptorchid rats showed the same activities. The change in isoproterenol-responsive adenylate cyclase was independent of the age at which the animals were made cryptorchid. The isoproterenol response was maximal 3–4 weeks after the rats were made cryptorchid. By 2–3 months after orchidopexy the isoproterenol response in the rat testis had decreased to normal control values.
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