Abnormal gonadotrophin release from pituitaries of muscular dystrophic mice and hamsters

M. Wilkinson

doi:10.1530/jrf.0.0710463

Jump to Content

Abnormal gonadotrophin release from pituitaries of muscular dystrophic mice and hamsters

in Reproduction

Author:

M. Wilkinson

M. Wilkinson
Search for other papers by M. Wilkinson in
Current site
Google Scholar
PubMed

View More View Less

DOI:: https://doi.org/10.1530/jrf.0.0710463

Volume/Issue:: Volume 71: Issue 2

Page Range:: 463–466

Article Type:: Research Article

Online Publication Date:: Jul 1984

Free access

Download PDF

Summary. LHRH-stimulated LH and FSH secretion was studied in hemipituitaries, in vitro, obtained from several dystrophic mouse mutants (male: 129/ReJ-dy; 129B6F₁/J-dy; C57BL/6J-dy and C57BL/6J-dy^2J; female: 129B6F₁/J-dy) and a dystrophic hamster mutant (male and female CHF-147). Without exception, pituitary tissue from dystrophic animals released significantly more FSH than did tissue obtained from controls. LH secretion was more variable; in the male mice release was inhibited, whereas in the male dystrophic hamsters secretion was elevated above normal. The female mouse mutant pituitary released more LH whereas in the female hamster LH secretion was normal.

The reduction in body weight of the mutants studied could have contributed to the observations of impaired anterior pituitary function.

Reproduction is committed to supporting researchers in demonstrating the impact of their articles published in the journal.

The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.

More information is on the Reasons to publish page.