A monoclonal antibody to an antigen present on the microvillous membrane of the trophectoderm of the preimplantation blastocyst of the pig

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Authors:
A. Whyte
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,
M. Bacon
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, and
S. Ellis
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DOI:
https://doi.org/10.1530/jrf.0.0710599
Volume/Issue:
Volume 71: Issue 2
Page Range:
599–605
Article Type:
Research Article
Online Publication Date:
Jul 1984
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Summary. Immunization of BALB/c mice with 14-day pig preimplantation blastocyst material followed by fusion of spleen cells with NS-0 myeloma cells resulted in a clone, SN1/38, which secreted IgG1 which reacted specifically with the microvillous border of the pig trophectoderm and trophoblast as assessed by immunohistology. SN1/38 did not react with other fetal tissues, or with blastocysts from other animal species. It was shown by absorption studies and by enzyme-linked immunoabsorbent assay that SN1/38 was not directed against the placental form of pig alkaline phosphatase. The location of this antigen and its apparent presence throughout gestation indicate a functional role in the materno—fetal interaction.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899