Progressive infertility in female lethal yellow mice (Ay/a; strain C57BL/6J)

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Authors:
N. H. Granholm
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,
K. W. Jeppesen
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, and
R. A. Japs
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DOI:
https://doi.org/10.1530/jrf.0.0760279
Volume/Issue:
Volume 76: Issue 1
Page Range:
279–287
Article Type:
Research Article
Online Publication Date:
Jan 1986
Free access

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Summary. Obese Ay/a females of 120 days or older, when compared to age-matched a/a controls (strain C57BL/6J), exhibited abnormal oestrous cyclicity characterized by reduced frequencies of true oestrous-stage smears, decreased mating success to proven a/a males, lowered uterine weights, and depressed ovulation rates. Exogenous gonadotrophins (PMSG/hCG) partly restored ovulation in obese Ay/a females to near control levels, demonstrating the sensitivity of Ay/a ovarian tissues to FSH and LH, at least at superovulatory levels. Concentrations of endogenous gonadotrophins and/or sensitivity of ovarian target cells to gonadotrophins may therefore be impaired in obese Ay/a females. Aberrant copulatory behaviour, reduced uterine weights, and depressed conception rates strongly suggest ovarian steroid deficiencies, perhaps secondary effects of reduced endogenous gonadotrophin activity. As in other obese rodent syndromes (e.g. ob/ob, db/db, and fa/fa), a possible fundamental Ay-induced hypothalamic lesion is consistent with our data.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899