Differential regulation by LH and prostaglandins of steroidogenesis in small and large luteal cells of the ewe
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Introduction
In a nonfertile cycle, the corpus luteum of the ewe secretes progesterone for about 2 weeks, and then regresses and is resorbed within the ovary. Luteolysis does not occur, however, if fertilization takes place. In fact, luteolysis must be prevented for pregnancy to be successful. The most important function of the corpus luteum appears to be the secretion of progesterone, since removal of the corpus luteum in early gestation causes abortion, but abortion is prevented by progesterone therapy (Amoroso & Perry, 1977).
Since progesterone plays a crucial role in the establishment and maintenance of early pregnancy, elucidation of the factors which regulate progesterone secretion is important for understanding the mechanisms involved in the maternal recognition of pregnancy. Perhaps the most important factors involved in the regulation of progesterone secretion are luteinizing hormone (LH) and the prostaglandins. LH stimulates progesterone secretion by luteal tissue and can maintain luteal function in
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| Sept 2018 onwards | Past Year | Past 30 Days | |
|---|---|---|---|
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