Increasing ovulation rate and lambing rate in sheep by treatment with a steroid enzyme inhibitor

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R. Webb
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Summary. Treatment of ewes with a 3β-hydroxysteroid dehydrogenase (3β-HSD) inhibitor (Epostane) resulted in a significant increase in both ovulation rate and in the mean number of lambs per ewe lambing. The progestagen sponge plus 3β-HSD inhibitor treatment also caused a significant increase in oestrous cycle duration of approximately 1·5 days. Treatment of ewes with the 3β-HSD inhibitor caused a significant decrease in peripheral progesterone concentrations, which were reduced even further when 3β-HSD inhibitor treatment was given to ewes after insertion of a progestagen sponge. However, mean oestradiol concentrations were significantly higher in the two treatment groups, both at the end of the luteal phase and during the follicular phase of the oestrous cycle. These results demonstrate that ovulation rate and the production of lambs per ewe lambing can be significantly increased by 3β-HSD inhibitor treatment.

 

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