Effects of prostaglandins E-2 and F-2α on the metabolism of [U-14C]glucose by mouse morulae–early blastocysts in vitro

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Authors:
N. K. Khurana
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R. G. Wales
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DOI:
https://doi.org/10.1530/jrf.0.0790275
Volume/Issue:
Volume 79: Issue 1
Page Range:
275–280
Article Type:
Research Article
Online Publication Date:
Jan 1987
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Summary. During 5-h culture in the presence of radioactive glucose, PGE-2 (10 μg/ml) significantly inhibited incorporation of glucose into the acid-soluble glycogen pool. PGE-2 at 1 and 10 μg/ml and PGF-2α at 1 μg but not 10 μg/ml stimulated incorporation of glucose into non-glycogen macromolecules during culture. However, the utilization of acid-soluble glycogen and other biochemical pools was not affected by the presence of PGs in the medium during 24-h chase culture of pulse-labelled embryos. Carbon dioxide production was significantly suppressed in the presence of PGs but accumulation of lactate was not affected. The results indicate that PGE-2 and PGF-2α, in physiological concentrations, directly influence the metabolism of glucose by preimplantation embryos.

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Print ISSN:
1470-1626
Online ISSN:
1741-7899