Effect of systemic intravenous infusion of PGF-2α and 13,14-dihydro-15-keto-PGF-2α on the release of oxytocin-associated neurophysin from the ovary in the ewe

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W. B. Watkins
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L. G. Moore
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Summary. Systemic intravenous infusion of physiological concentrations of PGF-2α and its major metabolite, 13,14-dihydro-15-keto-PGF-2α (PGFM) into non-pregnant ewes possessing a corpus luteum induced the release of oxytocin—neurophysin. These results suggest that, during luteolysis, endogenous release of uterine PGF-2α would be able to stimulate the release of ovarian oxytocin and oxytocin—neurophysin from the ovary.

 

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