Inhibition of ovulation, steroidogenesis and collagenolytic activity in rabbits by sulpiride-induced hyperprolactinaemia

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Authors:
K. C. Lin
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,
N. Kawamura
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H. Okamura
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, and
T. Mori
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DOI:
https://doi.org/10.1530/jrf.0.0830611
Volume/Issue:
Volume 83: Issue 2
Page Range:
611–618
Article Type:
Research Article
Online Publication Date:
Jul 1988
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Summary. Ovulation induced by hCG in rabbits was reduced significantly (P < 0·005) by sulpiride-induced hyperprolactinaemia. The pre- and post-ovulatory increases in peripheral and ovarian venous progesterone (but not oestradiol or testosterone) were suppressed in the treated animals. The condition of hyperprolactinaemia also prevented the usual changes in 2,4-dinitrophenyl-Pro-Gln-Gly-Ile-Ala-Gly-Gln-d-Arg-OH peptidase (DNP-peptidase) and α-N-benzoyl-dl-Arg-β-naphthylamide hydrolase (BANA-hydrolase) activities in follicular tissue that had been stimulated by an ovulatory dose of hCG. These results suggest that inhibition of progesterone production and collagenolytic enzyme activity by sulpiride-induced hyperprolactinaemia may be responsible for the ovulatory dysfunction that occurs when a mammal has a high level of circulating prolactin.

Keywords: ovulation; steroidogenesis; proteolytic enzyme; hyperprolactinaemia; rabbit

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Print ISSN:
1470-1626
Online ISSN:
1741-7899