An intra-uterine suture did not evoke any acute changes in the rat uterus. However, prolonged presence of the suture provoked keratinized metaplasia of the epithelium in 20% of the animals and cystic glandular hyperplasia in 10%. The O2 uptake rate was doubled in the treated horn but other biochemical constituents did not undergo any noteworthy change. Pregnancy was invariably prevented in the treated horn. However, this effect was reversed by removal of the suture provided there were no gross abnormalities in the uterus. Animals fitted with the suture before puberty also conceived only in the control horn when their fertility was tested during adult life. The removal of the suture led to pregnancy in both horns. This indicated that the reproductive potential of these animals was not disturbed due to the insertion of the suture during prepuberal life.
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