Differential binding of (+) and (−) gossypol to plasma protein and their entry into rat testis

in Reproduction
Authors:
J. M. Wang
Search for other papers by J. M. Wang in
Current site
Google Scholar
PubMed Close
,
L. Tao
Search for other papers by L. Tao in
Current site
Google Scholar
PubMed Close
,
X. L. Wu
Search for other papers by X. L. Wu in
Current site
Google Scholar
PubMed Close
,
L. X. Lin
Search for other papers by L. X. Lin in
Current site
Google Scholar
PubMed Close
,
J. Wu
Search for other papers by J. Wu in
Current site
Google Scholar
PubMed Close
,
M. Wang
Search for other papers by M. Wang in
Current site
Google Scholar
PubMed Close
, and
G. Y. Zhang
Search for other papers by G. Y. Zhang in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.1530/jrf.0.0950277
Volume/Issue:
Volume 95: Issue 1
Page Range:
277–282
Article Type:
Research Article
Online Publication Date:
May 1992
Free access

Sign up for journal news

Summary. Concentrations of (+) and (−) gossypol were measured by high performance liquid chromatography after they were incubated with plasma proteins in vitro. The concentration of (−) gossypol decreased more than the concentration of (+) gossypol. A similar decrease in free gossypol concentrations in the blood plasma of rats was observed after intravenous infusion of gossypol enantiomers. The concentration of (−) gossypol was also found to be lower than the concentration of (+) gossypol at the blood–testis barrier. The biological effect of (−) gossypol probably results from its stereospecific binding to extra- and intracellular proteins in vivo and inhibition of the biological activity of some proteins.

Keywords: gossypol enantiomers; HPLC; protein binding; blood–testis barrier; rat

Reproduction is committed to supporting researchers in demonstrating the impact of their articles published in the journal.

The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.

More information is on the Reasons to publish page.

Sept 2018 onwards Past Year Past 30 Days
Full Text Views 189 75 14
PDF Downloads 89 29 6

 

  • Collapse
  • Expand
Print ISSN:
1470-1626
Online ISSN:
1741-7899