Genes encoding the α and β chains of follicle-stimulating hormone are not sites for the Booroola (FecB) mutation in sheep

in Reproduction
Authors:
G. W. Montgomery
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J. M. Penty
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J. A. Sise
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H. M. Tou
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DOI:
https://doi.org/10.1530/jrf.0.0950895
Volume/Issue:
Volume 95: Issue 3
Page Range:
895–901
Article Type:
Research Article
Online Publication Date:
Aug 1992
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Summary. Bovine cDNA probes for the β-subunit of follicle-stimulating hormone β (FSHβ) and the α-subunit of the glycoprotein hormones identify genetic variation (polymorphic restriction fragments) near these genes in sheep. The inheritance of the polymorphic restriction fragments was studied in half-sibling pedigrees generated by mating heterozygous (B+) rams to non-carrier (++) ewes so that the co-inheritance or genetic linkage to the Booroola (FecB) locus and the α- and β-subunits of FSH could be analysed. Genetic recombination was observed between the FSHβ locus and the FecB locus in all five families studied and between the α-subunit and the FecB locus in the two families studied. We conclude that the FecB mutation does not lie within the FSH β- or α-subunit genes encoding the heterodimeric hormone FSH, and that the high concentrations of FSH observed in carrier ewes must result from indirect actions of the FecB mutation on the synthesis, processing, storage, release or metabolism of FSH.

Keywords: FSHβ; α-subunit; FecB gene; sheep; Booroola; RFLP analysis; genetic linkage

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Print ISSN:
1470-1626
Online ISSN:
1741-7899