Changes in activities of superoxide dismutase and lipid peroxide in corpus luteum during pregnancy in rats

in Reproduction
Authors:
N. Sugino
Search for other papers by N. Sugino in
Current site
Google Scholar
PubMed Close
,
Y. Nakamura
Search for other papers by Y. Nakamura in
Current site
Google Scholar
PubMed Close
,
O. Takeda
Search for other papers by O. Takeda in
Current site
Google Scholar
PubMed Close
,
M. Ishimatsu
Search for other papers by M. Ishimatsu in
Current site
Google Scholar
PubMed Close
, and
H. Kato
Search for other papers by H. Kato in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.1530/jrf.0.0970347
Volume/Issue:
Volume 97: Issue 2
Page Range:
347–351
Article Type:
Research Article
Online Publication Date:
Mar 1993
Free access

Sign up for journal news

Activities of superoxide dismutase (SOD) and lipid peroxide (LPO) were studied in corpora lutea of pregnant rats. SOD activities, both Mn-SOD and Cu,Zn-SOD, gradually increased in the corpora lutea until day 15 of pregnancy and decreased thereafter until day 21 of pregnancy, in a similar manner to serum progesterone concentration. LPO activities remained low until day 15 of pregnancy, but increased rapidly after day 15 to day 21 of pregnancy. Incubation of the dispersed luteal cells from day 15 of pregnancy in vitro showed that FeSO4 and ascorbic acid, which induce lipid peroxidation, significantly inhibited progesterone secretion. The inhibitory effects of FeSO4 and ascorbic acid were blocked by the simultaneous addition of α-tocopherol. These results suggest important roles for SOD and LPO in regulating luteal function during pregnancy.

Reproduction is committed to supporting researchers in demonstrating the impact of their articles published in the journal.

The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.

More information is on the Reasons to publish page.

Sept 2018 onwards Past Year Past 30 Days
Full Text Views 553 395 0
PDF Downloads 169 64 0

 

  • Collapse
  • Expand
Print ISSN:
1470-1626
Online ISSN:
1741-7899