Mitochondrial DNA in mammalian reproduction

in Reviews of Reproduction
Author:
J Cummins
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DOI:
https://doi.org/10.1530/revreprod/3.3.172
Volume/Issue:
Volume 3: Issue 3
Page Range:
172–182
Article Type:
Research Article
Online Publication Date:
01 Sep 1998
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Mitochondrial DNA (mtDNA) forms a semi-autonomous asexually reproducing genome in eukaryotic organisms. It plays an essential role in the life cycle through the control of energy production, by the inherently dangerous process of oxidative phosphorylation. The asymmetric nature of its inheritance--almost exclusively through the female--imposes different evolutionary constraints on males and females, and may lie at the heart of anisogamy. This review examines the implications of recent findings on the biology of mtDNA for reproduction and inheritance in mammals.

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Print ISSN:
1359-6004