Inhibitory effect of melatonin on GnRH-induced LH release

in Reviews of Reproduction
Author:
J Vanecek
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DOI:
https://doi.org/10.1530/revreprod/4.2.67
Volume/Issue:
Volume 4: Issue 2
Page Range:
67–72
Article Type:
Research Article
Online Publication Date:
01 May 1999
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Melatonin inhibits GnRH-induced release of LH and FSH from the neonatal, but not the adult, rat anterior pituitary gland. This action of melatonin is mediated by the specific high-affinity membrane-bound receptors that are absent in adult rats. The intracellular mechanism of melatonin action involves a decrease in intracellular calcium [Ca2+]i in the gonadotrophs; melatonin inhibits GnRH-induced Ca2+ release from endoplasmic reticulum as well as Ca2+ influx through voltage-sensitive channels. Melatonin also inhibits GnRH-induced accumulation of cAMP, which may result in the decreased influx of Ca2+, because cAMP, acting through protein kinase A, stimulates Ca2+ influx into the gonadotrophs. This age-dependent effect of melatonin on gonadotrophin release from the pituitary may be involved in the timing of puberty.

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Print ISSN:
1359-6004